Association between HBV mutations and HBV-related acute-on-chronic liver failure
ZHANG Ai-min
WANG Hui-fen
LI Gui-ying
LI Yu
DUAN Xue-zhang
Abstract：Objective To investigate the association between HBV mutations and the development of acute-on-chronic liver failure (ACLF) in patients with chronic HBV infection. Methods A total of 87 HBV-related ACLF (HBV-ACLF) patients were enrolled in the study, and 52 age-and sex-matched patients with chronic hepatitis B (CHB) and 51 patients with liver cirrhosis (LC) were selected as controls. The mutations at HBV basic core promoter, pre-core, and partial C regions were determined by nest-ed PCR and direct sequencing methods. The association between HBV mutations and the development of ACLF was analyzed. Results The average numbers of mutations in CHB, LC and ACLF groups were 2.31, 3.55 and 3.86, respectively. As compared with CHB group, ACLF group had more mutations at nt1762, nt1846, nt1899 and nt1913; as compared with LC group, ACLF had fewer mutations at nt1764, and more mutations at nt1846 and nt1913; as compared with CHB group, LC group had more mutations at nt1753, nt1762, nt1764 and nt1899. Multivariable analysis indicated that A1846T and C1913(A/G) mutations were independent fac-tors for ACLF. Conclusion HBV nucleotide mutations of A1846T and C1913(A/G) may be closely associated with the development of ACLF.
Keywords：hepatitis B virusliver failureacutehepatitis Bmutation rate
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 74-77,81 )