Observation of the Effect of Artemisia argyi L.cv.Beiai on Chronic Pharyngitis in Rabbits

MA Shengming; JIANG Zhihui; GU Lingbiao; WENG Shaoting; XING Yueteng; ZHAO Guofeng; ZHANG Kunpeng

doi:10.19329/j.cnki.1673-2928.2023.06.019

Abstract：The aim of this study was to investigate the effect of Artemisia argyi L.cv.Beiai on chronic pharyngitis in rabbits.A rabbit model of chronic pharyngitis was established in 3-month-old rabbits using a combination of ammonia and turpentine and turpentine following clinical diagnostic criteria.Once membrane formation was successful,rabbits were administered Artemisia argyi L.cv.Beiai powder in their drinking water for a duration of 14 days,with honeysuckle administration used as a positive control.Additionally,a natural recovery group and a normal group were established.Throughout the experimental period,clinical manifestations,body temperature,white blood cell classification,pharynx pathology,and inflammatory expression were observed and compared among the groups.The results revealed prominent clinical symptoms of chronic pharyngitis in the model rabbits,including extensive pharyngeal tissue necrosis and widespread neutrophil infiltration.In comparison to the natural recovery group,rabbits administered Artemisia argyi L.cv.Beiai exhibited a normalization of clinical features,weight gain,stable body temperature,reduced lymphocytes and monocytes in the blood,and mild lymphocyte infiltration in the pharynx.Furthermore,transcription levels of inflammatory factors TNF-α,IL-1 β and IL-6 were significantly diminished.The findings indicate that Artemisia argyi L.cv.Beiai effectively mitigates clinical symptoms related to chronic pharyngitis in rabbits.It also improves the inflammatory pathology of pharynx tissue and inhibit the transcription of inflammatory factors.