Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury
Zi-wei Zhou
Ya-dan Li
Wei-wei Gao
Jie-li Chen
Shu-yuan Yue
Jian-ning Zhang
摘要：A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and ex-plored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats (cold water swimming for 3 minutes at 4℃) spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34+ stem cells and new blood vessels in the injured hippocampus tissue increased sig-nificantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.
机标关键词：traumatic brain injurycold waterprogenitor cellsVon Willebrand factorperipheral bloodblood vesselsrat model
资助基金：This study was supported by a grant from the Incubation Project of Natural Science Foundation of Tianjin Medical University Gen-eral Hospital in China, (No. 303071901401)the Natural Science Foundation of Tianjin of China, (No. 13JCZDJC30800)the National Natural Science Foundation of China, (No. 81271361 and 81330029)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1322-1328 )
英文信息