Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction
Yong-dong Yang
Xing Yu
Xiu-mei Wang
Xiao-hong Mu
Feng He
摘要：Tanshinone IIA, extracted fromSalvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inlfammatory, anti-oxidative and anti-apoptotic properties. hTis study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inlfammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion (L6–S1) cells was less atfer treatment with tanshinone IIA. hTe effects of tanshinone IIA were similar to intra-venous injection of 30 mg/kg methylprednisolone. hTese ifndings suggested that tanshinone IIA improved functional recovery atfer spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.
机标关键词：tanshinone IIAspinal cord injuryneuroprotective effectsdorsal root ganglion
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 267-275 )
英文信息