MicroRNA expression profiles and functions in the brain
Yanting Qi
Yu Zhao
Zhuyin Chen
Xiaona Chen
Marie C. Lin
Xiangfu Kong
Lihui Lai
摘要：MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates.
机标关键词：neurodegenerative diseasespathological processesexpression patternbrain tumors
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1380-1385 )
英文信息