Research Progress on the Mechanisms of Diuretic-Induced Acute Kidney Injury
Abstract：Acute kidney injury refers to a clinical syndrome characterized by a rapid decline in renal function within a short period due to various causes. Patients typically present with reduced urine output, elevated blood urea nitrogen, creatinine, disorders of water, electrolyte, and acid-base balance, and in severe cases, a multisystem syndrome. Among drug-induced kidney injuries, diuretics rank third, following antibiotics and contrast agents. The mechanisms of kidney injury caused by diuretics include direct nephrotoxicity, acute interstitial nephritis, disturbances in water and electrolyte balance, abnormalities in renal hemodynamics, osmotic nephropathy, abnormalities in uric acid and lipid and carbohydrate metabolism, and intrarenal or postrenal obstruction. A thorough understanding of the mechanisms of diuretic-induced kidney injury is beneficial for physicians and pharmacists to use diuretics more rationally in clinical practice and to avoid the occurrence of kidney injury.
Keywords：DiureticsAcute Kidney InjuryInjury Mechanism
Publication Date：2025-11-15
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：5( 61-65 )