A Case Report of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Combined with Ankylosing Spondylitis
Abstract：Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) is caused by the t(9;22)(q34;q11) translocation on the long arm of chromosome 9, and it is a high-risk subtype of ALL, accounting for 20% to 30% of adult ALL cases. The prognosis is poor, with a long-term survival rate below 20%. The incidence increases with age, and patients over 60 years old account for 50% of ALL cases [1]. The typical features of Ph+ALL include older age, frequent association with high white blood cell counts, hepatosplenomegaly, and lymphadenopathy, and it is prone to involve the central nervous system. When the central nervous system is infiltrated, intrathecal chemotherapy is the most effective treatment and preventive measure [2-3]. Cases of Ph+ALL combined with ankylosing spondylitis (AS) are rare. In these patients, the spine is often fused into a mass, making lumbar puncture difficult and preventing intrathecal drug administration, which leads to significant challenges in treatment and suboptimal outcomes. This article reviews the clinical characteristics, diagnosis, and treatment process of a case of Ph+ALL combined with AS treated at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, and conducts a literature review to enhance awareness of this disease.
Keywords：acute lymphoblastic leukemiaphiladelphia chromosome positiveankylosing spondylitisdiagnosistreatment
Publication Date：2025-04-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 342-345,352 )