Advances in the Diagnosis of Hemophagocytic Syndrome
Abstract：Hemophagocytic syndrome (HPS), also known as hemophagocytic lymphohistiocytosis (HLH), belongs to a rare and life-threatening systemic inflammatory syndrome. Its clinical manifestations generally include persistent fever, cytopenia, hepatosplenomegaly, and phagocytosis of blood cells in organs or tissues. HLH can be divided into primary HLH (pHLH) and secondary HLH (sHLH): pHLH has a clear family history of genetic disease or is associated with gene defects related to HLH, and it often occurs in childhood; sHLH is usually induced by acquired factors such as infections, malignancies, and rheumatologic diseases. When HLH is secondary to rheumatologic diseases, it is referred to as macrophage activation syndrome (MAS)[1].
Keywords：hemophagocytic syndromehemophagocytic lymphohistiocytosisdiagnosis
Publication Date：2025-04-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 330-335 )