Large-scale Rearrangements in BRCA1/2 Genes in Ovarian Cancer
Abstract：Ovarian cancer is the gynecological tumor with the highest mortality rate. More than 70% of ovarian cancer patients are diagnosed at stage III/IV, and the 5-year survival rate for patients with advanced ovarian cancer is less than 30%. In 2020, there were 314,000 new cases of ovarian cancer worldwide, and as many as 207,000 deaths [1]. Ovarian cancer is one of the most hereditary cancers, among which the breast cancer susceptibility genes BRCA1 and BRCA2 play an important role. Approximately 15% to 20% of high-grade serous ovarian cancers (HGS) are associated with pathogenic mutations in BRCA1/2, and 65% to 75% of patients with hereditary ovarian cancer have pathogenic mutations in BRCA1/2.
Keywords：ovarian cancerBRCA genelarge genomic rearrangementNGS
Publication Date：2025-10-02
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：4( 1053-1056 )