Evidence Summary and Comparison of Pre-eclampsia: Finding Common Ground and Respecting Differences (Part 2)
Abstract：1 Prevention of Pre-eclampsia (Pre-eclampsia, PE)
1.1 Aspirin In recent years, guidelines have consistently recommended that high-risk pregnant women should start taking aspirin prophylactically in early pregnancy [1-2]. However, there are differences among guidelines regarding the dosage, gestational age at initiation, and timing of discontinuation of aspirin. See Table 1.
The risk level of high-risk pregnant women and different specifications of aspirin are the main factors affecting the dosage of aspirin. The International Society for the Study of Hypertension in Pregnancy (ISSHP) recommends that high-risk pregnant women identified by the multiple-variable prediction of the Foundation for Fetal Medicine (FMF) should be given 150 mg of aspirin nightly; while high-risk pregnant women identified based on clinical risk factors and blood pressure should be given 100–162 mg of aspirin nightly. In the United States, the common specification of aspirin is 81 mg, while in China it is 100 mg, and the recommended effective doses vary from 50–162 mg/day across guidelines. Therefore, countries or regions can choose an appropriate dose based on aspirin specifications and individual conditions of pregnant women.
Keywords：pre-eclampsiaguideline recommendationspreventionevidence-based medicinemanagementpostpartum follow-up
Publication Date：2025-07-02
Online Publishing Date：2025-08-19(First online date of this platform, not the publication date of the document)
Pages：5( 764-768 )