Expert Consensus on the Construction and Clinical Translation of Endometrial Organoids (2025 Edition)
Abstract：During each menstrual cycle, the endometrium of women undergoes cyclical changes regulated by estrogen and progesterone [1]. The metabolic and genomic characteristics of the endometrium vary at different stages of life and different phases of the menstrual cycle, and there is significant heterogeneity between individuals. Abnormal changes in the endometrium can lead to various endometrial diseases. Endometrial damage can cause Asherman syndrome, and abnormal endometrial regeneration may result in intrauterine adhesions, infertility, and recurrent miscarriage [2]; endometriosis occurring in the myometrium or outside the uterus can lead to adenomyosis and endometriosis, often presenting with dysmenorrhea, chronic pelvic pain, heavy menstruation, and infertility [3]; abnormal proliferation and differentiation of the endometrium can lead to complex hyperplasia or endometrial cancer. These endometrial diseases significantly affect the quality of life of women of reproductive age and postmenopausal women. Understanding the mechanisms of occurrence and development of endometrial diseases and seeking new therapeutic targets can help achieve early and personalized diagnosis and treatment. However, the highly dynamic and heterogeneous nature of the endometrium, as well as ethical issues, pose significant challenges in studying the physiological changes of the endometrium and the pathological processes of related diseases.
Keywords：endometrial diseaseorganoidsclinical translationexpert consensus
Publication Date：2025-03-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 212-219 )