Effect Analysis of Combination Therapy with Benazepril Hydrochloride Tablets and Digoxin Tablets in Patients with Hypertension Combined with Heart Failure

doi:10.16458/j.cnki.1007-0893.2025.18.018

Abstract：Objective: To explore the clinical efficacy of combination therapy with benazepril hydrochloride tablets and digoxin tablets in patients with hypertension combined with heart failure (HF). Methods: A retrospective analysis was conducted on the clinical data of 123 patients with hypertension combined with HF who were treated at Luoyang Eastern People's Hospital from February 2022 to January 2024. The patients were divided into three groups according to the treatment method: Group A (43 cases, receiving benazepril hydrochloride tablets combined with digoxin tablets), Group B (41 cases, receiving benazepril hydrochloride tablets alone), and Group C (39 cases, receiving digoxin tablets alone). The clinical efficacy, blood pressure, heart rate, cardiac function, vascular regulatory mediators, and incidence of adverse reactions were compared among the three groups before and after treatment. Results: The total effective rate of Group A was higher than that of Groups B and C, with statistically significant differences (P < 0.05). After treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate of Group A were lower than those of Groups B and C, with statistically significant differences (P < 0.05). After treatment, the left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) of Group A were smaller than those of Groups B and C, while the left ventricular ejection fraction (LVEF) was higher than that of Groups B and C, with statistically significant differences (P < 0.05). After treatment, the serum levels of endothelin-1 (ET-1) and thromboxane B2 (TXB2) in Group A were lower than those in Groups B and C, while the serum level of nitric oxide (NO) was higher than that in Groups B and C, with statistically significant differences (P < 0.05). There was no statistically significant difference in the overall incidence of adverse reactions among the three groups (P > 0.05). Conclusion: The combination of benazepril hydrochloride tablets and digoxin tablets can effectively reduce blood pressure and heart rate in patients with hypertension combined with HF, improve vascular endothelial function and cardiac function, without increasing the risk of adverse reactions.