Application Effect of Eight Treasures Decoction in Patients with Colorectal Cancer After Surgery and Chemotherapy

doi:10.16458/j.cnki.1007-0893.2025.18.013

Abstract：Objective: To explore the application effect of Eight Treasures Decoction in patients with colorectal cancer after surgery and chemotherapy. Methods: A total of 60 patients with colorectal cancer who were treated at Xinyang Traditional Chinese Medicine Hospital from January 2021 to December 2024 were selected as the study subjects and randomly divided into a control group and an observation group, each with 30 cases. The control group received capecitabine combined with oxaliplatin chemotherapy, while the observation group received additional treatment with modified Eight Treasures Decoction on top of the control group's regimen. The therapeutic effects, nutritional status, serum tumor marker levels, and incidence of adverse reactions before and after chemotherapy were compared between the two groups. Results: The clinical remission rate of the observation group was higher than that of the control group, with a statistically significant difference (P < 0.05). There was no statistically significant difference in the clinical control rate between the two groups (P > 0.05). After chemotherapy, the hemoglobin (Hb) and serum albumin (ALB) levels of the observation group were higher than those of the control group, with statistically significant differences (P < 0.05). After treatment, the serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in the observation group were lower than those in the control group, with statistically significant differences (P < 0.05). The incidence of gastrointestinal reactions and myelosuppression in the observation group was lower than that in the control group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the incidence of neurotoxicity and skin-mucosal reactions between the two groups (P > 0.05). Conclusion: Modified Eight Treasures Decoction as an adjuvant therapy for patients with colorectal cancer after surgery and chemotherapy can improve clinical efficacy, enhance nutritional status, regulate serum tumor marker levels, and alleviate gastrointestinal reactions and myelosuppression caused by chemotherapy.