Effect of Sitagliptin Combined with Estradiol Valerate Tablets on Patients with Polycystic Ovary Syndrome and Its Impact on Glycometabolic Indicators
Abstract：Objective: To explore the clinical efficacy of sitagliptin combined with estradiol valerate tablets in the treatment of patients with polycystic ovary syndrome (PCOS) and its impact on glycometabolic indicators. Methods: A total of 166 PCOS patients who visited the Xia County People's Hospital from January 2022 to December 2024 were selected as the study subjects and randomly divided into a sitagliptin group and a control group, with 83 cases in each group. The control group received metformin combined with estradiol valerate tablets, while the sitagliptin group received sitagliptin combined with estradiol valerate tablets. The treatment effects, glycometabolic indicators, hormone six items, lipid metabolism indicators, and incidence of adverse reactions before and after treatment were compared between the two groups. Results: The total effective rate of the sitagliptin group was higher than that of the control group, with a statistically significant difference (P < 0.05). After treatment, the levels of hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), 2-hour postprandial glucose (2h PG), fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), androstenedione (A2), triglycerides (TG), and total cholesterol (TC) in the sitagliptin group were lower than those in the control group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Sitagliptin combined with estradiol valerate tablets can effectively alleviate the clinical symptoms of PCOS patients, improve glycometabolism and hormonal disorders, reduce lipid metabolism indicators, and has high safety.
Keywords：Polycystic Ovary SyndromeSitagliptinEstradiol Valerate TabletsGlycometabolismLipid Metabolism
Publication Date：2025-09-15
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：4( 75-78 )