Effect of Huatan Tongluo Decoction on Neurological Function and Cerebral Hemodynamics in Patients with Ischemic Stroke (Qi Deficiency Phlegm Stasis Syndrome)

doi:10.16458/j.cnki.1007-0893.2025.15.015

Abstract：Objective: To investigate the effect of Huatan Tongluo Decoction on neurological function and cerebral hemodynamics in patients with ischemic stroke (ischemic stroke, Qi deficiency phlegm stasis syndrome) during the recovery period. Methods: A total of 168 patients with ischemic stroke in the recovery period treated at Xinyang Traditional Chinese Medicine Hospital from March 2023 to January 2025 were selected as the study subjects. They were randomly divided into a western medicine group (receiving conventional western medicine treatment) and a combined group (receiving Huatan Tongluo Decoction in addition to western medicine treatment), with 84 cases in each group. The scores of traditional Chinese medicine syndromes, neurological function indicators [myelin basic protein (MBP), neuron-specific enolase (NSE)], cerebral hemodynamics indicators, and incidence of adverse reactions were compared between the two groups. Results: After treatment, the scores of all traditional Chinese medicine syndromes (hemiplegia, speech difficulty, edema of hands and feet, fatigue) in both groups were lower than those before treatment, and the combined group had lower scores than the western medicine group, with statistically significant differences (P < 0.05). After treatment, the serum levels of MBP and NSE in both groups were lower than before treatment, and the combined group had lower levels than the western medicine group, with statistically significant differences (P < 0.05). After treatment, the resistance index (RI) and pulsatility index (PI) of the middle cerebral artery in both groups were lower than before treatment, and the combined group had lower values than the western medicine group; the mean flow velocity (Vm) was higher than before treatment, and the combined group had higher values than the western medicine group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Treating patients with ischemic stroke using Huatan Tongluo Decoction can significantly improve clinical symptoms, neurological function, and cerebral hemodynamics, without increasing adverse reactions.