Clinical Study on the Treatment of Colorectal Cancer Liver Metastasis with Self-Designed Wind-Removing and Mass-Resolving Formula Based on the Theory of 'Wind Toxin Invading the Meridians' Combined with mFOLFOX6 Regimen
Abstract：Objective: To investigate the clinical efficacy and safety of a self-designed wind-removing and mass-resolving formula based on the theory of 'wind toxin invading the meridians' combined with the mFOLFOX6 regimen (fluorouracil, leucovorin, and oxaliplatin) in the treatment of colorectal cancer (CRC) liver metastasis. Methods: A total of 60 patients with CRC liver metastasis admitted to Longhua Hospital Jiangxi Branch, Shanghai University of Traditional Chinese Medicine from January 2023 to December 2024 were selected as the study subjects and randomly divided into a control group and an observation group, with 30 patients in each group. The control group received the mFOLFOX6 regimen, while the observation group received the wind-removing and mass-resolving formula combined with the mFOLFOX6 regimen. The clinical efficacy, TCM syndrome scores, tumor marker levels, quality of life, and incidence of adverse reactions were compared between the two groups. Results: The objective response rate (ORR) and disease control rate (DCR) of the observation group were higher than those of the control group, with statistically significant differences (P < 0.05). After treatment, the TCM syndrome scores, serum carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) levels of the observation group were lower than those of the control group, with statistically significant differences (P < 0.05). The improvement rate of quality of life in the observation group was higher than that in the control group, while the reduction rate was lower, with statistically significant differences (P < 0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The self-designed wind-removing and mass-resolving formula based on the theory of 'wind toxin invading the meridians' combined with the mFOLFOX6 regimen can effectively control CRC liver metastasis, improve patient symptoms and tumor marker levels, enhance their quality of life, and does not increase adverse reactions.
Keywords：Colorectal CancerLiver MetastasisWind Toxin Invading the MeridiansWind-Removing and Mass-Resolving Formula
Publication Date：2025-05-30
Online Publishing Date：2025-09-15(First online date of this platform, not the publication date of the document)
Pages：4( 34-37 )