Clinical Evidence and Mechanisms of Bariatric Surgery in Improving Obesity-Related Cardiovascular Risk
Abstract：Studies have shown that obesity [body mass index (BMI) ≥30 kg/m2] is significantly associated with the risk of cardiovascular disease (CVD). In Asian populations, CVD mortality increases exponentially when BMI exceeds 25 kg/m2. Visceral fat accumulation can directly damage cardiovascular function by activating the renin-angiotensin system, inducing insulin resistance (IR), and causing chronic inflammation, leading to left ventricular hypertrophy, endothelial dysfunction, and atherosclerosis. This review aims to analyze the evidence-based rationale and molecular pathways through which surgery improves CVD, providing an integrated perspective for clinical decision-making.
Keywords：Bariatric surgeryCardiovascular riskGastric bypassSleeve gastrectomyMetabolic syndromeChronic inflammationCardiac remodeling
Publication Date：2025-08-20
Online Publishing Date：2025-09-24(First online date of this platform, not the publication date of the document)
Pages：7( 61-67 )