Research Progress on Metabolic Reprogramming and Ischemic Stroke
Abstract：Ischemic stroke (IS) refers to the sudden narrowing or occlusion of cerebral blood vessels, leading to severe cerebral hypoperfusion and subsequent brain tissue necrosis [1]. Over the past decade, the incidence and mortality of IS have continued to rise, with major risk factors including hypertension, diabetes, smoking, and hyperlipidemia [2]. Currently, the main treatments for IS are recombinant tissue-type plasminogen activator (r-tPA) and endovascular mechanical thrombectomy. However, these methods need to be performed within 4.5–9.0 hours after symptom onset, limiting the possibility of timely treatment for many patients [3].
Keywords：Ischemic StrokeMetabolic ReprogrammingGlucose MetabolismAmino Acid MetabolismLipid MetabolismOxidative Stress ResponseInflammatory Response
Publication Date：2025-08-28
Online Publishing Date：2025-09-18(First online date of this platform, not the publication date of the document)
Pages：6( 731-736 )