Research Progress on Hypoxia-Inducible Factor 1 in the Treatment of Chronic Refractory Wounds
Abstract：Clinically, wounds that have not shown signs of healing after more than one month of treatment due to various causes are defined as chronic refractory wounds [1]. The pathogenesis of these wounds is complex and diverse, with underlying causes including vascular diseases, metabolic disorders, immune dysfunction, infection, and other factors. Although these etiologies differ, they share common mechanisms in the process of wound non-healing: local circulatory impairment leads to a lack of oxygen and nutrients, thereby hindering cell regeneration and repair; prolonged inflammatory responses and abnormal extracellular matrix remodeling are also common characteristics of chronic refractory wounds, affecting the normal tissue repair processes required for wound healing.
Keywords：Hypoxia-Inducible Factor 1Chronic Refractory WoundDeep Burn WoundDiabetic WoundRadiation Injury WoundOlder Wound
Publication Date：2025-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 355-360 )