Effect of Nano-Selenium on the Liver Antioxidant Capacity, Immune Organ Index, and Immune Performance of Finishing Pigs

doi:10.3969/j.issn.1001-0769.2025.02.007

Abstract：To investigate the effects of nano-selenium on the liver antioxidant capacity, immune organ index, and immune performance of finishing pigs, this experiment selected 'Duroc × Landrace × Yorkshire' three-way crossbred finishing pigs with body weight of 75-80 kg, which were randomly divided into 4 groups. Group A (control group) was fed a basal diet, while Groups B, C, and D were fed experimental diets with 0.3, 0.5, and 0.7 mg/kg of nano-selenium added to the basal diet, respectively. The results showed that the liver antioxidant capacity, immune organ index, and immune performance of the finishing pigs in Groups B, C, and D were improved to varying degrees compared to those in Group A. Among them, the glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, and immunoglobulin A (IgA) content in the liver of the finishing pigs in Groups B, C, and D were significantly different from those in the control group (P < 0.01). The catalase (CAT) activity in the liver of Group C was significantly different from that of the control group (P < 0.05). The total antioxidant capacity (T-AOC), malondialdehyde (MDA), IgM, and complement 4 (C4) content in the liver of Groups C and D were significantly different from those of the control group (P < 0.01). The spleen index of Group C was significantly different from that of the control group (P < 0.01), and the thymus index of Groups C and D was significantly different from that of the control group (P < 0.05). The IgG and C3 contents in the serum of Groups B and C were significantly higher than those of the control group (P < 0.05), while those of Group D were extremely significantly higher than those of the control group (P < 0.01). Except for MDA, the spleen index, thymus index, and liver antioxidant capacity indicators of Group D were slightly lower than those of Group C. The results indicate that adding 0.5 mg/kg of nano-selenium to the diet has the best effect on improving the liver antioxidant capacity, immune organ index, and immune performance of finishing pigs.